Jimi Hendrix's mixed-handedness, and the ensuing enhancement of interaction between the left and right sides of his brain, resulted in a synergetic confluence of factors that led to both his groundbreaking style of guitar playing and the engaging and provocative nature of his songs and lyrics. Perhaps the most important aspect of the current paper, from the perspective of handedness researchers, is the argument that modern “right-handed” guitars are better viewed as left-handed guitars in terms of the relative motor demands on the two hands, and that Hendrix's superlative guitar abilities arose from the fact that he played a “left-handed” guitar and was thus able to use his more dextrous right hand on the guitar's fretboard.
via informaworld.com